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br Membrane receptor Indirect non genomic signaling As menti
2019-12-09
Membrane receptor: Indirect non-genomic signaling As mentioned above, not all JIB-04 synthesis responses fit the classical genomic model of steroid action. The observation of excessively fast estrogen-induced biological responses led to the development of the hypothesis that estrogen could be act
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br Transparency document br Acknowledgments This
2019-12-09
Transparency document Acknowledgments This study was funded by ICMR, Govt. of India. Alisha Dhiman acknowledges UGC-DSKPDF, India for post-doctoral fellowship and Monisha Gopalani acknowledges CSIR, India for Senior Research Fellowship. AIRF, JNU is acknowledged for TEM, confocal microscopy an
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br Results br Discussion Many studies have shown that
2019-12-09
Results Discussion Many studies have shown that intrinsic properties of the E2 enzyme govern the nature of the Ub modification, including both the multiplicity of the Ub modification and the specific Tubastatin A HCl synthesis type in the case of polyubiquitin chains [3], [4], [9], [14]. Wher
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This hydrophobic biphenyl tail gave good binding
2019-12-09
This hydrophobic biphenyl tail gave good binding affinity for human DHODH enzyme (IC corresponding DTP3 was found to be the main metabolite in human microsomes and it was 100-fold less active against hDHODH than the ester. In an attempt to identify the specific non-covalent binding interactions wh
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Natural and synthetic glucocorticoids perform their
2019-12-09
Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors). It has been determined that glucocorticoid receptors cross-talk with other nuclear receptors, including AhR (Celander et al.
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br Discussion The use of carp primary cell
2019-12-06
Discussion The use of carp primary cell cultures proved to be a valuable approach to evaluate the piscine immune response. A. hydrophila was a more potent stimulator of NO formation by carp leukocytes compared to commercial LPS often used for leukocyte stimulation (Mustafa and Olson, 1998, Chao e
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It has been reported that the
2019-12-06
It has been reported that the ECD of DDRs require dimerization and/or oligomerization for binding to collagen.,, Here, we have established using SPR that antibody-mediated oligomerization of DDR2-Fc significantly enhances its binding to immobilized collagen type 1. Our results are consistent with ea
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Caffeine During the host response to inflammation inflammato
2019-12-06
During the host response to inflammation, inflammatory mediators, including release of pro-inflammatory cytokines, have been associated with altered content, expression, and activity of CYP450 enzymes, consequently leading to alterations in the metabolism and elimination of certain drugs. The losses
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The development of C S mutation has been reported in
2019-12-06
The development of C797S mutation has been reported in vivo in a small cohort (15 subjects) of EGFR T790M positive patients progressing after Osimertinib: this tertiary mutation was found, using a droplet digital PCR (ddPCR) assay, in 40% of patients after AR to this agent, while 33% of the cases ex
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OHC is a potent regulator
2019-12-06
25-OHC is a potent regulator of LXR-mediated pathways, that impact on glycoprotein iib iiia inhibitors lipid homeostasis [8]. This oxysterol affects expression of the cholesterol efflux pumps ATP-binding cassette transporter (ABC)A1 [9] and ABCG1, and expression of apolipoprotein E [10], [11], [12]
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br Experimental Procedures br Author Contributions br
2019-12-06
Experimental Procedures Author Contributions Acknowledgments Introduction Breast cancer is one of the most common malignancies for women worldwide, representing approximately 22% of women’s malignancies that pose a threat to women’s health [[1], [2], [3], [4]]. The morbidity rate of brea
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abt 888 MuRF interacts with four and a half LIM
2019-12-06
MuRF3 interacts with four-and-a-half LIM domain (FHL2) and γ-filamin leading to their degradation via UPS [64]. Conversely, abnormal aggregation of these proteins was observed in mice lacking MuRF3. Moreover, MuRF3-/- mice were found more prone to cardiac rupture after acute myocardial infarction (A
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Everolimus treatment showed an increase in the number of
2019-12-06
Everolimus treatment showed an increase in the number of plaques and a reduction in plaque size, depending on concentration and treatment time (Fig. 1, Fig. 2). Everolimus-pretreated gsk-3 adsorbed less virus with more plaque formation in the initial phase of infection (Fig. 3). The ability and eff
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Extracellular uridine can be transported across
2019-12-06
Extracellular uridine can be transported across the cell membrane to enter the nucleotide salvage pathway. A colon cancer cell line supplemented with uridine was capable of growing normally in the presence of 1 μM brequinar (Peters et al., 1992). The supplemented uridine may be transported into the
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DNA promoter hypermethylation is an
2019-12-06
DNA promoter hypermethylation is an important mechanism in epigenetic modulation of gene expression.[16], [17], [18] When the promoter CpG island of a gene is hypermethylated, the transcription and its associated function of the gene will be subsequently altered.[19], [20], [21] In human cancers, we